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IPLUSO 19560

Clinical-Laboratory Hematology II

Biomedical Laboratory Sciences
  • ApresentaçãoPresentation
    Hematology studies how blood cells under normal and abnormal conditions. Students will be instructed in the theory and application of hematology procedures, including quality control, quality assurance, safety, manual and / or automatic methods, as well as normal and altered blood cell maturation sequences and morphology with appropriate practice associated disease.
  • ProgramaProgramme
    Anaemias Pathophysiological classification Morphological classification Diagnostic approach to anaemia Polyglobulias .Primary Secondary Non-malignant changes of leukocytes Malignancies of granulocytes Acute myeloblastic leukaemia Chronic Myeloid Leukaemia Myelodysplastic Syndromes Hematological malignancies of lymphocyte Leukaemias lymphocytic Hodgkin's and non-Hodgkin's´lymphoma Laboratory study of haemostasis  Manual and automatic methods Pathology of haemostasis Primary Secondary Brief notions used in major therapeutic groups of hemopathies Anaemias Benign Leukocytopaties Leukocytopaties malignancies Changes of haemostasis and fibrinolysis Automatic Study of erythrocytes, leukocytes and platelets Cytograms and histograms. Analysis of clinical cases.
  • ObjectivosObjectives
    Students should: 1) Understand the bone marrow microenvironment and the molecular mechanisms of haematological oncogenesis, including signalling pathways and epigenetics. 2) Relate genetic alterations to classification, prognosis and targeted therapies. 3) Characterise myeloid, lymphoid and plasma-cell neoplasms. 4) Integrate full blood count findings with peripheral blood and bone marrow morphology. 5) Explain the principles of flow cytometry and interpret immunophenotypic profiles. 6) Integrate morphological, immunophenotypic, cytogenetic and molecular data in the diagnostic assessment of haematological neoplasms. 7) Distinguish reactive from clonal alterations in leucocyte and platelet lineages. 8) Morphologically identify the main haemoparasites. 9) Recognise the pathophysiological and laboratory foundations of haemostasis, with an introductory approach to von Willebrand disease and haemophilias.
  • BibliografiaBibliography
    Antovic, J. P., & Magnusson, M. (Eds.). (2025). Blombäck's essential guide to blood coagulation: A practical guide to diagnosis and treatment of hemostatic disorders (3rd ed.). Wiley-Blackwell. Bain, B. J., Bates, I., & Laffan, M. A. (2016). Dacie and Lewis practical haematology (12th ed.). Elsevier. Bain, B. J., & Leach, M. (2025). Blood cells: A practical guide (7th ed.). Wiley-Blackwell. Hoffbrand, A. V., Chowdary, P., Collins, G. P., & Loke, J. (2026). Fundamentos em hematologia de Hoffbrand (9.ª ed.). Artmed. Keohane, E. M., Preston, M. M., Mirza, K. M., & Walenga, J. M. (Eds.). (2024). Rodak's hematology: Clinical principles and applications (7th ed.). Elsevier. Pádua, M. M. (2011). Patologia clínica para técnicas: Hematologia-citologia (Tomo III). Lusodidacta. Porwit, A., & Béné, M.-C. (Eds.). (2025). Multiparameter flow cytometry in the diagnosis of hematologic malignancies (2nd ed.). Cambridge University Press.  
  • MetodologiaMethodology
    In practical classes, the student has prior access to the experimental protocols to be carried out in each class session, which allows for prior reading and preparation. These protocols are accompanied by a set of questions, to ensure individual preparation and, subsequently, the discussion of procedures and results.
  • LínguaLanguage
    Português
  • TipoType
    Semestral
  • ECTS
    5
  • NaturezaNature
    Mandatory
  • EstágioInternship
    Não