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IPLUSO 19559

Clinical-Laboratory Hematology I

Biomedical Laboratory Sciences
  • ApresentaçãoPresentation
    The curricular unit of Clinical Laboratory Hematology is based on an integrated and functional view of the sciences and technologies applied to diagnosis. It aims to endow the students with skills that enable them, within a multidisciplinary team, to contribute to the best quality of care delivery. Its main objectives are to promote the acquisition of new knowledge and laboratory methodologies applied to Hematology and to address the integrated laboratory areas, in a multidisciplinary, cross-sectional and integrative perspective, as a contribution to the correct prognostic and predictive assessment of the disease, as well as the response to therapy.
  • ProgramaProgramme
    General notions Hematology Blood (functions, composition) Hematopoiesis Notions of proliferation and apoptosis Hematopoietic organs Hematological parameters used in a laboratory routine Essential factors for erythropoiesis Iron Vitamin B12 Folic acid Haemoglobin Structure of the molecule Heme biosynthesis Physiological erythrocyte hemolysis Morphological changes in the red blood cell Size Shape Content Granulocytopoiesis Kinetics of myeloid cells Functions of granulocytes Cytochemical and immunological markers Mononuclear phagocyte system Monocytopoiesis Lymphocytopoiesis B lymphocytes and humoral response T Lymphocyte and cell response Automatic study of erythrocytes and leukocytes Physiology of Hemostasis Primary Secondary Exploration of the fibrinolytic system Inhibitors and activators
  • ObjectivosObjectives
    Students should: 1) Understand haematopoiesis, the differentiation and maturation of the different lineages, and blood-cell morphology and function. 2) Relate erythropoiesis, hemoglobin, iron, B12 and folate, distinguishing structural hemoglobin variants from thalassaemic syndromes. 3) Classify anaemias and select laboratory parameters. 4) Apply pre-analytical and biosafety requirements and recognise non-conformities. 5) Perform procedures, carry out calculations, and interpret automated hemoglobin, hematocrit, and red-cell index results. 6) Explain haematology automation and interpret full blood counts, histograms, scattergrams and flags. 7) Identify normal cells, red-cell abnormalities and artifacts by light microscopy. 8) Explain hemostasis, fibrinolysis and the effects of antithrombotics. 9) Integrate pre-analytical, instrumental, and morphological data in technical validation and report results accurately.
  • BibliografiaBibliography
    Bain, B. J., Bates, I., & Laffan, M. A. (2016). Dacie and Lewis practical haematology (12th ed.). Elsevier. Bain, B. J., & Leach, M. (2025). Blood cells: A practical guide (7th ed.). Wiley-Blackwell. Hoffbrand, A. V., Chowdary, P., Collins, G. P., & Loke, J. (2026). Fundamentos em hematologia de Hoffbrand (9.ª ed.). Artmed. Keohane, E. M., Preston, M. M., Mirza, K. M., & Walenga, J. M. (Eds.). (2024). Rodak's hematology: Clinical principles and applications (7th ed.). Elsevier. Lichtman, M. A., Kaushansky, K., Prchal, J. T., Levi, M. M., Burns, L. J., & Linch, D. C. (2022). Williams manual of hematology (10th ed.). McGraw Hill. Pádua, M. M. (2011). Patologia clínica para técnicas: Hematologia-citologia (Tomo III). Lusodidacta.    
  • MetodologiaMethodology
    In practical classes, the student has prior access to the experimental protocols to be carried out in each class session, which allows for prior reading and preparation. These protocols are accompanied by a set of questions, to ensure individual preparation and, subsequently, the discussion of procedures and results.
  • LínguaLanguage
    Português
  • TipoType
    Semestral
  • ECTS
    5
  • NaturezaNature
    Mandatory
  • EstágioInternship
    Não