IPLUSO 19294

Organic Pharmaceutical Chemistry

• ApresentaçãoPresentation

  It is intended to provide the necessary foundations for the interpretation of the representation of organic compounds and identification of functional groups, with particular focus on those most frequently found in drugs and biomolecules. It is also intended to provide the necessary basis for understanding the discovery, design and development of drugs, structure and function of pharmacological targets, and the concepts of pharmacodynamics, pharmacokinetics, quantitative structure-activity relationships (QSAR), use of computational chemistry and some classes of drugs with application in pharmaceutical chemistry. Students should be able to use Applied Chemistry tools for drug synthesis and  Methods for drug analysis. They must know the parameters of the QSAR establishment, predict the type of pharmacokinetic profile and pharmacodynamic profile and, in practical classes, they must gather knowledge of organic synthesis and analytical methods.
• ProgramaProgramme

  Program contents: Introduction and general concepts. 1. Structure and chemical bond of organic molecules. 2. Constitution of organic molecules: functional groups, nomenclature and isomerism. 3. Reactivity, mechanistic and kinetic aspects. Pharmacological targets: structure and function. 1. Proteins, enzymes, receptors, and nucleic acids. Pharmacodynamics and pharmacokinetics. 1. Absorption, distribution, metabolism and excretion of drugs (ADME). Discovery, design and development of drugs. 1. Discovery of drugs: identification of the prototype. 2. Pharmaceuticals Design: optimization of target access and interactions with the therapeutic target. Computational Chemistry. Quantitative structure-activity relations (QSAR) Selected Topics in Pharmaceutical Chemistry. 1. Antibacterial agents. 2. Antiviral agents. 3. Anticancer agents. 4. Cholinergic, anticholinergics, and anticholinesterases. 5. Drugs that act on the adrenergic nervous system. 6. Opioid analgesics. 7. Antiulcer agents.
• ObjectivosObjectives

  From the theoretical point of view students should be able to use the tools of Organic Chemistry for the synthesis of drugs and those of the analytical methods of drugs. They must also know the determining parameters in the establishment of structure-activity relations. For each drug example, the type of pharmacokinetic profile presented should be predicted: absorption and distribution based on lipophilicity, metabolism and excretion based on the structure and also know the respective pharmacodynamic profile always in view of the target site duality, therapeutic objective. From a practical point of view, students should gather knowledge of organic synthesis with respect to laboratory practice and be able to apply their theoretical knowledge in the development of new drug synthesis pathways, nd erspective qualitative and quantitative analysis.
• BibliografiaBibliography

    1. Patrick, G. L. (2005). An Introduction to Medicinal Chemistry. Oxford: University Press. 2. Thomas, G. (2008). Medicinal Chemistry: An Introduction. New Jersey: John Wiley & sons. 3. Vollhardt, K. P. C., Schore,  N. E. (2014). Organic Chemistry: structure and function. New York: Freeman and Company. 4. Clayden, J., Greeves, N., Warren, S., Wothers, P. (2001). Organic chemistry. Oxford ; New York : Oxford University Press. 5. Foye, W.O., Lemke, T. L., Williams, D. A. (2012). Principles of Medicinal Chemistry. Philadelphia: Lippincott Williams & Wilkins. 6. Proença da Cunha, A., Costa, Maria do Céu, Pereira, A.  et al., Manual de Plantas Medicinais- Bases Clínicas e Farmacológicas, ISBN: 9789725766637Edição ou reimpressão: 10-2017, Editor: Dinalivro, Lisboa. 7. Curtis D. Klaassen, John B. Watkins III. Fundamentos em Toxicologia de Casarett e Doull - 2ª Edição. ISBN: 9788580551310.  Editora: MCGRAW-HILL.  
• MetodologiaMethodology

  In this curricular unit, the Team-based learning (TBL) methodology is used, with tasks carried out in small groups, allowing the development of the ability to analyze and apply theoretical concepts
• LínguaLanguage

  Português
• TipoType

  Semestral
• ECTS

  6
• NaturezaNature

  Mandatory
• EstágioInternship

  Não